Research at Quincy Bioscience
Research is taking place both within Quincy Bioscience as well as partnering with academic laboratories and research institutions.
Madison Memory Study
The study protocol builds upon the evidence in previous pilot studies which demonstrated apoaequorin improved memory as measured by participant reported outcomes. The technology which MMS uses to measure cognitive changes in participants is a computer based assessment using software developed by CogState Ltd., a global provider of cognitive testing products and services. Participants were tested at baseline and then re-assessed four more times during the three month period.
Prevagen contains apoaequorin which has been shown to help improve memory in clinical studies. Apoaequorin is a protein that was originally discovered in jellyfish and now produced at our cGMP compliant and NSF certified facility in Wisconsin.
Safety studies conducted on the toxicity and allergenicity of apoaequorin show that apoaequorin is safe. In rats following subchronic administration of amounts up to 666.7mg per kilogram of body weight per day Apoaequorin preparation did not result in any mortality.1 This was the maximum dosage that was tested. Researchers concluded,
“The administration of the Apoaequorin preparation did not result in any mortality. There were no further clinical or opthalmological signs, body weight, body weight gain, food consumption, food efficiency, clinical pathology, or histopathological changes attributable to administration of Apoaequorin.”2
Dosing in the study was the equivalent of 4,000 times the recommended daily amount of Prevagen 10mg and 2,000 times the recommended daily amount of Prevagen Extra Strength 20mg. In addition, apoaequorin achieved self-affirmed GRAS status (generally recognized as safe) after an independent panel of expert scientists concluded that apoaequorin is safe for use in food products.
1. Marone, P.A., Bauter, M., Hofman-Hüther, H., and Moran, D. (2013). Safety assessment of Apoaequorin, a protein preparation: Subchronic toxicity study in rats. Food and Chemical Toxicology 57.
2. Marone, P.A., Bauter, M., Hofman-Hüther, H., and Moran, D. (2013). Toxicologic Evaluation of the Calcium Binding Protein Apoaequorin. Poster presented at the Society of Toxicology Annual Meeting, San Antonio, Texas.